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Some bariatric practices, primarily these performed underneath public-funded companies, have adopted reaching a goal preoperative weight loss (PrWL) earlier than providing surgical procedure. There are assorted opinions on the correlation between preoperative and postoperative weight loss (PoWL) for the completely different surgical choices. This examine investigated the impression of goal PrWL on PoWL for sufferers who underwent laparoscopic sleeve gastrectomy (LSG).

Supplies and strategies

A longitudinal retrospective cohort examine was carried out on sufferers who had documented preoperative weight earlier than LSG (n=155) from the authors’ establishment between February 2008 to October 2017. Sufferers had been grouped into two cohorts primarily based on assembly the 5% goal PrWL or not. The endpoint included p.c postoperative weight loss (% PoWL) at one yr and two to a few years.


A complete of 155 people had been recognized and analysed. Of those sufferers, 78.7% of them (n=122) achieved the 5% goal PrWL (goal group) whereas 21.3% (n= 33) didn’t (non-target group). At one yr, there was no statistical important distinction within the imply % PoWL between the non-target and goal teams (22.3 ± 8.1% versus 19.4 ± 11.8% p worth= 0.08). The same remark was made at two-three years, the place the imply % PoWL within the non-target group was 14.7 ± 10.7% versus 16.3 ± 14.4% within the goal group (p worth= 0.07). Our additional evaluation highlighted a statistically important weak inversely proportional correlation between % PrWL and % PoWL at one yr and two to a few years.


Assembly goal PrWL doesn’t considerably impression on PoWL after LSG. Due to this fact, it shouldn’t function exclusion standards for eligible sufferers who’re in want of surgical procedure.


The stark epidemic proportion of weight problems is a actuality in right this moment’s world [1]. The World Well being Group (WHO) in 2014 revealed estimates that present a staggering 39% of adults to be obese and 13% overweight [2]. Weight problems is related to comorbidities resembling metabolic illness (resembling sort 2 diabetes), cardiovascular and joint illness, sure sorts of most cancers, discount in self-reported high quality of life, and elevated mortality in the long term [3]. It poses an enormous well being burden on the person and has a big societal pressure by way of prices related to human sources, administration, and long-term affected person administration [4].

Surgical intervention has been proven to end in better enchancment by way of weight loss and obesity-associated comorbidities when put next with non-surgical interventions, whatever the process [5]. This epidemic proportion of weight problems has witnessed an attendant improve in laparoscopic bariatric surgical procedure worldwide with estimates of about 468,609 procedures carried out as of 2013. Probably the most important rise was that of laparoscopic sleeve gastrectomy (LSG) from Zero to 37% of the world whole from 2003 to 2013 [6].

The factors set out by the Nationwide Institutes of Well being (NIH) Consensus Growth Convention panel for sufferers requiring gastric restriction or bypass procedures embody well-informed and motivated sufferers with acceptable operative dangers, physique mass index (BMI) exceeding 40 or between 35 and 40 with comorbidities (resembling extreme sleep apnoea, diabetes mellitus) and obesity-induced bodily issues. It doesn’t stipulate necessary goal preoperative weight loss (PrWL) [7].

Goal PrWL is usually inspired amongst bariatric practitioners primarily public service funded companies, earlier than present process bariatric surgical procedure to enhance affected person compliance and outcomes [8-10]. Nonetheless, the impression of PrWL on a postoperative final result resembling postoperative weight loss (PoWL) has remained controversial [11]. Some have challenged the requirement and efficacy of a preoperative goal weight loss earlier than present process bariatric process [12].

Due to this fact, there may be nonetheless a must additional examine the importance of PrWL on PoWL, particularly in sufferers who underwent LSG.

Supplies & Strategies

This examine utilised de-identified information from our bariatric database of sufferers on the authors’ establishment.

Cohort choice

We recognized all sufferers who underwent any bariatric operation (gastric band, Roux-en-Y gastric bypass, sleeve gastrectomy, or revisional surgical procedure) (n=339) from February 2008 to October 2017. A complete of 166 LSG had been carried out (included 11 revisions from gastric bands to LSG); nonetheless, observe up information for 155 sufferers had been obtained and people with out documented postoperative weight after one yr excluded from the evaluation. Sufferers had been labeled as “goal” and “non-target” classes primarily based on assembly the 5% goal PrWL or not, and the 2 teams had been in contrast.


We centered on two variables. P.c PrWL (% PrWL) was decided by subtracting the burden at surgical procedure from the recorded weight at referral to the bariatric service (preliminary weight) divided by preliminary weight multiplied by 100. P.c PoWL (% PoWL) was outlined because the distinction of the post-surgery weight at one, or two-three years from weight at surgical procedure over the preliminary weight and expressed as a share.

Final result measure

Our main final result was % PoWL at one-year and two-three years follow-up. At our establishment, we observe up postoperative weights three months to 24 months postoperatively.

The Pearson correlation coefficient (r) was used to measure the connection between each variables. F-test was used to find out the general statistical significance of this relationship. All information evaluation was carried out with Microsoft Excel 2013.


Information from 155 sufferers was analysed. The median age was 50 years and there have been extra feminine than male sufferers. The typical BMI at referral to the bariatric companies (begin BMI) was 48.5 Kgm-2. The typical BMI at surgical procedure was 43.Eight Kgm-2 reflecting a median internet weight loss preoperatively from a median of 135.1 Kg to 119.7 Kg at surgical procedure. As seen in Determine 1, of the 155 sufferers, 78.7% of sufferers (n=122) achieved the 5% PrWL (goal) whereas 21.3% (n=33) didn’t (non-target). The youngest topic was 26 years and the oldest 62 years on the time of surgical procedure. 

At one yr, sufferers who didn’t meet 5% goal PrWL had a median % PoWL of 22.3 ±8.1% versus 19.4 ±11.8% for many who met 5% goal PrWL (p worth = 0.08) (Determine 2A).

At two to a few years, the typical % PoWL for sufferers who didn’t meet the 5% goal PrWL was 14.7 ±10.7% (Determine 2B). This was barely decrease than the typical % PoWL (16.3 ±14.4%) recorded within the cohort of topics who met the 5% PrWL goal (p worth =0.07).

Within the goal group, the correlation between PrWL and PoWL at one and two to a few years are detailed in Figures 34.

Within the non-target group of sufferers, an identical relationship between each parameters was noticed (Figures 56).

Analysing mixed information from all sufferers who underwent an LSG is depicted in Figures 78.


Bariatric (weight loss) surgical procedure as at right this moment is protected, efficient in producing important sustainable weight loss, and results in the enchancment or decision of co-morbidities related to weight problems [13-14]. LSG as a bariatric possibility has quickly gained recognition and is taken into account the second most carried out bariatric process on the planet [15]. Regardless of the elevated acceptance of weight loss surgical procedure, lower than 1% of eligible candidates find yourself receiving surgical procedure in some climes [16]. In endeavor bariatric companies, some establishments have adopted a coverage of goal PrWL citing benefits resembling diminished peri-operative morbidity, decreased working time with much less blood loss, and attainable motivation for additional weight loss [17].

On the authors’ establishment, the vast majority of the sufferers participated within the hospital’s preoperative program and are anticipated to attain a goal weight loss of 5% earlier than present process surgical procedure. Nonetheless, some who didn’t meet the goal weight loss however moderately fulfilled the NIH Consensus Growth Convention and the Scottish Nationwide Planning Discussion board (NPF) pointers after bariatric multidisciplinary crew (MDT) assessment, had been supplied surgical procedure. We sought to find out whether or not goal PrWL impacted considerably on PoWL. Our examine noticed no robust correlation between PrWL and PoWL amongst the sufferers that had LSG at one and two-three years postoperative years.

In a meta-analysis finished in 2011 involving 17 trials and 10 research by Cassie et al. and a most up-to-date one in 2014 by Gerber et al. (included 23 publications and two assessment articles), the authors had been inconclusive in regards to the impact of PrWL because of the heterogeneity within the numerous examine designs [3,9].

In a single-center assessment of 192 sufferers who underwent LSG throughout a nine-month examine interval, Parmar et al. reported no correlation between those that misplaced ‘excessive’ or ‘low’ preoperative weight (primarily based on comparability to the median p.c PrWL of 5.1%) and postoperative weight at one yr [18].

One other examine by Sherman et al. of their assessment of 141 sufferers additionally recognized that PrWL is just not a dependable predictor of PoWL [11]. Watanabe A et al. of their work famous that the extent of PrWL didn’t contribute to raised weight loss in the course of the general interval [15]. Our findings additional align with the above research that focus on PrWL doesn’t considerably impression on PoWL after LSG.

We recognise the limitation of this examine given its single institutional non-randomised assessment nature, which can elevate the potential of choice bias and will not completely mission the broader bariatric inhabitants.


Our examine noticed that reaching goal PrWL doesn’t considerably impression PoWL as reported in earlier research. Eligible bariatric candidates shouldn’t be denied surgical procedure primarily based on track PrWL. We advocate additional potential trials to delineate the impression of PrWL on LSG outcomes.